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Updated: Aug 18, 2026
Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins
Published on: August 15, 2017
Monosodium-L-glutamate-induced convulsions--I. Differences in seizure pattern and duration of effect as a function of
Abstract:
Convulsive activity in 3, 10, 60 and 180-day old Sprague-Dawley rats was studied following the i.p. administration of 4 mg g-1 of commercial MSG. The latency period increased with the age of the animals while the duration of the convulsive period was longer in younger animals and shorter in 60-day old rats. Convulsions were predominantly tonic in 3 and 10-day old rats, tonic-clonic in 60-day old rats, and predominantly clonic in 180-day old animals. The severity of the convulsions and death incidence increased progressively with age. Animals injected either with sodium chloride equimolar to MSG or physiological saline solution showed no convulsive activity. The effects of MSG without trace metals were no different from those produced by commercial MSG.
