Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Toxicity of acetaminophen overdose.

R G Peterson, B H Rumack

    JACEP
    |May 1, 1978
    PubMed
    Summary

    Acetaminophen (APAP) overdose causes liver toxicity 24-48 hours post-ingestion. Early treatment within 12 hours with agents like N-acetylcysteine dramatically reduces mortality and liver damage.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    4-Methylpyrazole protects against acetaminophen hepatotoxicity in mice and in primary human hepatocytes.

    Human & experimental toxicology·2018
    Same author

    A single-arm clinical trial of a 48-hour intravenous N-acetylcysteine protocol for treatment of acetaminophen poisoning.

    Clinical toxicology (Philadelphia, Pa.)·2014
    Same author

    Submaxillary duct and gland stones; report of a case.

    Journal of oral surgery·2010
    Same author

    Ranula (cystic tumor); report of case.

    Journal of oral surgery·2010
    Same author

    Bilateral osteotomy of the mandibular rami for correction of prognathism in an edentulous mouth; report of case.

    Journal of oral surgery·2010
    Same author

    Compound composite odontome of the mandible.

    Journal of oral surgery·2010

    Area of Science:

    • Toxicology
    • Pharmacology
    • Hepatology

    Background:

    • Acetaminophen (APAP) is a common household medication with potential for overdose.
    • APAP toxicity primarily affects the liver, with the exact mechanism still under investigation.
    • The toxic dose varies, influenced by individual glutathione levels.

    Purpose of the Study:

    • To review the clinical presentation and management of acetaminophen overdose.
    • To emphasize the importance of early diagnosis and intervention in reducing mortality and liver toxicity.
    • To discuss the role of N-acetylcysteine as a potential treatment.

    Main Methods:

    • Review of clinical data on acetaminophen overdose.
    • Emphasis on diagnostic methods, including plasma APAP level measurement.
    • Discussion of treatment protocols and supportive care.

    Main Results:

    • Supportive care alone has a 5-10% mortality rate and high incidence of hepatic toxicity.
    • Treatment initiated within 10-12 hours of ingestion reduces mortality to zero and lessens liver damage.
    • N-acetylcysteine is an investigational treatment requiring enrollment in a nationwide evaluation.

    Conclusions:

    • Early detection and prompt therapeutic intervention are critical for managing acetaminophen toxicity.
    • Plasma APAP levels are essential for diagnosis due to non-specific early symptoms.
    • Contraindications for certain treatments, such as diuresis and hemodialysis, should be noted.

    Related Experiment Videos