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[Functional liver cell heterogeneity].

D Häussinger, W Gerok

    Infusionstherapie Und Klinische Ernahrung
    |October 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Liver cells exhibit metabolic zonation, with distinct functions in different zones. This heterogeneity in ammonia and glutamine metabolism impacts liver disease pathogenesis and pH balance.

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    [Not Available].

    Zeitschrift fur Gastroenterologie·2015

    Area of Science:

    • Cellular biology
    • Biochemistry
    • Physiology

    Context:

    • Hepatocytes display functional heterogeneity based on their location within the liver acinus.
    • Metabolic zonation influences diverse liver functions, including gluconeogenesis, glycolysis, and drug metabolism.

    Purpose:

    • To elucidate the functional and metabolic differences between periportal and perivenous hepatocytes.
    • To explore the role of hepatocyte heterogeneity in ammonia and glutamine metabolism in liver disease.

    Summary:

    • Hepatocytes are metabolically zoned, with periportal cells favoring oxidative metabolism and urea synthesis, while perivenous cells are involved in glycolysis and drug metabolism.
    • An intercellular glutamine cycle between periportal and perivenous hepatocytes facilitates ammonia detoxification and bicarbonate elimination, crucial for pH homeostasis.

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  • This zonation is dynamic, influenced by hormonal, metabolic, and circadian factors.

    • Impact:

    • Understanding hepatocyte zonation provides insights into the pathogenesis of hyperammonemia in severe liver disease.
    • The intercellular glutamine cycle's role in ammonia and bicarbonate metabolism highlights the liver's importance in maintaining systemic pH balance.
    • Dysregulation of this cycle contributes to metabolic alkalosis observed in liver failure.