Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

309
Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
309

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Upstream structure of human ADH7 gene and the organ distribution of its expression.

Biochemical and biophysical research communications·1995
Same author

Serum carbohydrate-deficient transferrin: mechanism of increase after chronic alcohol intake.

Hepatology (Baltimore, Md.)·1995
Same author

Medical disorders of alcoholism.

The New England journal of medicine·1995
Same author

First-pass metabolism of alcohol. Absence of diurnal variation and its inhibition by cimetidine after evening meal.

Digestive diseases and sciences·1995
Same author

Significant increase of blood alcohol by cimetidine after repetitive drinking of small alcohol doses.

Alcoholism, clinical and experimental research·1995
Same author

The effect of chronic alcohol administration on cerulein-induced pancreatitis.

International journal of pancreatology : official journal of the International Association of Pancreatology·1995

Related Experiment Video

Updated: Mar 14, 2026

Assessment of Glutamine as a Fuel Source for Alveolar Macrophages Exposed to Chronic Ethanol Using an Extracellular Flux Bioanalyzer
08:37

Assessment of Glutamine as a Fuel Source for Alveolar Macrophages Exposed to Chronic Ethanol Using an Extracellular Flux Bioanalyzer

Published on: November 15, 2024

839

Decrease in microviscosity and cholesterol content of rat liver plasma membranes after chronic ethanol feeding.

S Yamada, C S Lieber

    The Journal of Clinical Investigation
    |December 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Chronic ethanol consumption increases liver plasma membrane fluidity. This effect is linked to a reduction in cholesterol content within these membranes, impacting cellular function.

    More Related Videos

    Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
    05:12

    Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

    Published on: June 23, 2023

    1.7K
    Histological Analyses of Acute Alcoholic Liver Injury in Zebrafish
    10:45

    Histological Analyses of Acute Alcoholic Liver Injury in Zebrafish

    Published on: May 25, 2017

    15.3K

    Related Experiment Videos

    Last Updated: Mar 14, 2026

    Assessment of Glutamine as a Fuel Source for Alveolar Macrophages Exposed to Chronic Ethanol Using an Extracellular Flux Bioanalyzer
    08:37

    Assessment of Glutamine as a Fuel Source for Alveolar Macrophages Exposed to Chronic Ethanol Using an Extracellular Flux Bioanalyzer

    Published on: November 15, 2024

    839
    Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
    05:12

    Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

    Published on: June 23, 2023

    1.7K
    Histological Analyses of Acute Alcoholic Liver Injury in Zebrafish
    10:45

    Histological Analyses of Acute Alcoholic Liver Injury in Zebrafish

    Published on: May 25, 2017

    15.3K

    Area of Science:

    • Biochemistry
    • Cell Biology
    • Hepatology

    Background:

    • Chronic ethanol intake is a significant factor in liver disease.
    • Ethanol's impact on cellular membranes, particularly liver plasma membranes, is not fully understood.
    • Membrane fluidity and lipid composition are crucial for liver cell function.

    Purpose of the Study:

    • To investigate the effects of chronic ethanol feeding on the lipid composition of liver plasma membranes.
    • To determine if chronic ethanol consumption alters the fluidity of hepatic plasma membranes.

    Main Methods:

    • Male Sprague-Dawley rats were used in the study.
    • Rats were fed liquid diets with ethanol (36% of energy) or isocaloric carbohydrate for 4-5 weeks.
    • Hepatic plasma membrane fluidity was assessed using fluorescence anisotropy.
    • Lipid composition, specifically cholesterol content, was analyzed.

    Main Results:

    • Chronic ethanol feeding led to increased fluidity in hepatic plasma membranes.
    • This increase in membrane fluidity was associated with a decrease in cholesterol content.
    • The observed changes in fluidity and cholesterol were specific to plasma membranes.

    Conclusions:

    • Chronic ethanol consumption alters liver plasma membrane properties.
    • Reduced cholesterol content in hepatic plasma membranes contributes to increased membrane fluidity.
    • These alterations may have significant implications for liver function and disease progression.