Serum copper and caeruloplasmin activity in experimental malignancies

Serum copper content and caeruloplasmin activity were measured in 595 Strain A male mice. The mice carried either benzo(a)pyrene induced fibrosarcoma, transplanted sarcoma-180, Dalton's lymphoma, or Ehrlich carcinoma. The serum copper concentration was raised in all the tumours when compared with normal controls. The observed fall in activity of caeruloplasmin during malignancy may be related to defective iron mobilization.