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Nodular (keloidal) scleroderma.

W D James, T G Berger, D F Butler

    Journal of the American Academy of Dermatology
    |December 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

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    Two patients with progressive systemic sclerosis developed unusual keloid-like nodules. This suggests a potential keloidal response to early scleroderma inflammation in susceptible individuals or skin areas.

    Area of Science:

    • Dermatology
    • Rheumatology
    • Pathology

    Background:

    • Progressive systemic sclerosis (PSS) is an autoimmune disease characterized by skin thickening and fibrosis.
    • Keloid formation is a complex fibroproliferative process of the skin.
    • The co-occurrence of these conditions is exceptionally rare.

    Observation:

    • Two patients diagnosed with PSS presented with keloid-like nodules.
    • These nodules developed within areas of thickened, sclerodermatous skin.
    • The lesions mimicked the clinical and histological appearance of keloids.

    Findings:

    • The development of keloidal-like nodules in PSS is an extremely unusual event.
    • This phenomenon is hypothesized to be a keloidal response to the early inflammatory phase of scleroderma.

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  • Predisposing factors may include genetic susceptibility to keloid formation or specific anatomical locations prone to keloids, such as the chest.

    • Implications:

    • This finding expands the spectrum of cutaneous manifestations in progressive systemic sclerosis.
    • It highlights the potential for aberrant wound healing responses in scleroderma.
    • Further research is warranted to elucidate the precise mechanisms and identify at-risk patient populations.