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Related Experiment Videos

Short-term systems to assess thiophosphoryl chloride standards.

D Coloşi-Esca, Z Anca, F Barbarino

    Journal of Applied Toxicology : JAT
    |October 1, 1984
    PubMed
    Summary

    Thiophosphoryl chloride (PSCl3) shows toxicity in rats, with effects on organ weights and blood chemistry. However, it did not cause fetal malformations or mutagenicity, leading to a recommended workplace exposure limit.

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    Area of Science:

    • Toxicology
    • Occupational Health

    Background:

    • Thiophosphoryl chloride (PSCl3) is an industrial chemical requiring toxicological assessment.
    • Understanding its effects is crucial for workplace safety and risk management.

    Purpose of the Study:

    • To evaluate the toxicity of thiophosphoryl chloride (PSCl3) in a rat model.
    • To determine potential health risks associated with PSCl3 exposure.

    Main Methods:

    • Acute oral LD50 determination in rats.
    • 90-day subchronic oral feeding study with hematological and biochemical analysis.
    • Teratology and mutagenicity testing.
    • Assessment of organ weights and histopathological changes.

    Main Results:

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  • Acute oral LD50: 750 mg/kg.
  • Subchronic study showed increased body weight gain but inconsistent organ weight changes and significant hematological/biochemical alterations indicating toxicity.
  • Reversible liver dystrophic changes noted; potential for hepatitis reactivation.
  • No teratogenic or mutagenic effects observed.
  • Recommended maximum allowable concentration in air: 3 mg/m³.

    • Conclusions:

    • PSCl3 exhibits toxicity, affecting organ systems and blood parameters in rats.
    • Despite toxic effects, no developmental or genetic toxicity was detected.
    • A maximum allowable concentration of 3 mg/m³ is recommended for occupational settings.