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Short-term systems to assess thiophosphoryl chloride standards
Journal of Applied Toxicology : JAT
|October 1, 1984
Summary
Thiophosphoryl chloride (PSCl3) shows toxicity in rats, with effects on organ weights and blood chemistry. However, it did not cause fetal malformations or mutagenicity, leading to a recommended workplace exposure limit.
Area of Science:
- Toxicology
- Occupational Health
Background:
- Thiophosphoryl chloride (PSCl3) is an industrial chemical requiring toxicological assessment.
- Understanding its effects is crucial for workplace safety and risk management.
Purpose of the Study:
- To evaluate the toxicity of thiophosphoryl chloride (PSCl3) in a rat model.
- To determine potential health risks associated with PSCl3 exposure.
Main Methods:
- Acute oral LD50 determination in rats.
- 90-day subchronic oral feeding study with hematological and biochemical analysis.
- Teratology and mutagenicity testing.
- Assessment of organ weights and histopathological changes.
Main Results:
- Acute oral LD50: 750 mg/kg.
- Subchronic study showed increased body weight gain but inconsistent organ weight changes and significant hematological/biochemical alterations indicating toxicity.
- Reversible liver dystrophic changes noted; potential for hepatitis reactivation.
- No teratogenic or mutagenic effects observed.
- Recommended maximum allowable concentration in air: 3 mg/m³.
Conclusions:
- PSCl3 exhibits toxicity, affecting organ systems and blood parameters in rats.
- Despite toxic effects, no developmental or genetic toxicity was detected.
- A maximum allowable concentration of 3 mg/m³ is recommended for occupational settings.
