Related Experiment Video
Updated: Sep 11, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
[Multiple primary cancers in patients with malignant lymphoma]
Abstract:
This study of 502 patients with malignant lymphoma revealed the following: In all, 18 cases (3.6%) of histologically confirmed multiple primary cancers were found. Eleven cases of second malignancies were observed after diagnosis of malignant lymphoma, whereas 7 cases of malignant lymphoma occurred after other malignancies. The expected number of second malignancies in 502 patients with malignant lymphoma was calculated as 4.94 by the person-years approach. The observed number (11) was significantly higher than the expected (p less than 0.01). There was, however, no case of second malignancy considered to be related to the previous radiotherapy.
Related Concept Videos
Cancers Originate from Somatic Mutations in a Single Cell
Primary Lymphoid Organs
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Secondary Lymphoid Organs
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...

