[Prolonged nonbacterial meningitis: clinical aspects and cerebrospinal fluid findings]

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H Siemes, M Siegert

    Klinische Padiatrie
    |November 1, 1984
    PubMed

    Insights

    Prolonged aseptic meningitis in children can present with persistent symptoms and distinct cerebrospinal fluid (CSF) changes. Boys aged 6-15 showed more severe CSF abnormalities, indicating a prolonged inflammatory response.

    Area of Science:

    • Neurology
    • Pediatrics
    • Infectious Diseases

    Context:

    • Aseptic meningitis can lead to prolonged neurological symptoms in children.
    • Causative agents include mumps virus and enteroviruses.
    • Cerebral palsy may be a predisposing factor in some cases.

    Purpose:

    • To describe the clinical course and cerebrospinal fluid (CSF) findings in children with prolonged aseptic meningitis.
    • To identify potential differences in disease progression based on age and sex.

    Summary:

    • 33 children (2-15 years) with aseptic meningitis showed persistent CSF abnormalities (elevated protein/cell count) 10-28 days post-admission.
    • Two distinct CSF reaction patterns were observed: one with increased protein and minimal cells (all), and another with persistent elevation of both cells and protein, primarily in boys (6-15 years).
    • Complications included facial paralysis and transient hypertension; neurological symptoms like headache and vomiting persisted for weeks/months.

    Impact:

    • Highlights the potential for prolonged illness and distinct CSF profiles in pediatric aseptic meningitis.
    • Suggests sex-based differences in the inflammatory response and recovery patterns.
    • Informs clinical management and prognosis for children with persistent aseptic meningitis.

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