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Related Experiment Videos

[Progress on the way to an "artificial liver"].

G Brunner

    Leber, Magen, Darm
    |November 1, 1984
    PubMed
    Summary

    New enzyme fluid membrane technology enables continuous extracorporeal detoxification, removing toxins without enzyme loss or immune risks. This innovation advances towards partial liver function substitution.

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    Area of Science:

    • Biomedical Engineering
    • Biotechnology
    • Biochemistry

    Context:

    • Development of lipophilic fluid membrane hollow fiber modules for extracorporeal detoxification.
    • Addresses challenges of enzyme activity loss and immunological risks in current methods.

    Purpose:

    • To evaluate the efficacy of novel hollow fiber modules for enzymatic detoxification in vivo.
    • To assess clearance rates for specific toxins and enzymatic activity of immobilized enzymes.

    Summary:

    • Lipophilic fluid membrane hollow fiber modules facilitate continuous extracorporeal enzymatic detoxification.
    • Achieved phenol glucuronidation clearance of 6.8 nMol/min/mg enzyme protein/cm² and dodecanoic acid hydroxylation rate of 0.5 nMol/nMol P450/min/cm² using cytochrome P-450.
    • Enzyme-guided detoxification using methyl, sulfat, and glutathion transferases is under experimental investigation.

    Impact:

    • Presents a promising technology for efficient in vivo toxin elimination without compromising enzyme function or triggering immune responses.
    • Paves the way for developing partial extracorporeal liver function substitution by integrating with techniques like amino acid dialysis and plasma exchange.

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