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[Hematologic changes in renal neoplasms].

L Piccinini, E Croci, F Tavoni

    Minerva Medica
    |November 10, 1984
    PubMed
    Summary
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    Kidney tumor patients frequently exhibit anemia and leukocytosis, with anemia severity increasing with tumor stage. Mild thrombocytosis is also common, particularly in advanced kidney cancer.

    Area of Science:

    • Hematology
    • Oncology
    • Nephrology

    Context:

    • This study investigated hematological parameters in 146 kidney tumor patients.
    • Patients were categorized into four groups based on tumor stage and metastasis status.
    • Nephrectomy was performed on 119 patients.

    Purpose:

    • To analyze the correlation between kidney tumor progression and key hematological parameters.
    • To identify common hematological abnormalities in kidney cancer patients.

    Summary:

    • The study found a high prevalence of anemia (hemoglobin < 12 g/dl), increasing with tumor stage (41% in localized tumors to 79% in patients without proven metastasis).
    • Leukocytosis (white blood cell count > 8000/mm3) was also frequent (38-51% across groups).
    • Mild thrombocytosis (platelet count 350-500 X 10(3)/mm3) was observed, especially in advanced stages (20% in group II, 18% in group III), while leukopenia and thrombocytopenia were rare.

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    Impact:

    • Highlights the diagnostic and prognostic significance of hematological changes in kidney cancer.
    • Provides insights into the relationship between tumor burden and systemic inflammatory responses.
    • Suggests potential for monitoring kidney cancer progression through routine blood tests.