A human lymphocyte antigen is shared with a group of glycoproteins in peripheral nerve

The monoclonal antibody HNK-1 binds to a carbohydrate determinant in the myelin-associated glycoprotein (MAG) and other glycoproteins of human peripheral nerve. Some glycoproteins of lower Mr than the major P0 glycoprotein of myelin appear to bind more antibody than MAG. These glycoproteins electrophorese in the Mr range of 20,000 to 26,000 and are present in the purified myelin fraction. The results indicate that an antigen on the surface of a subset of lymphocytes is shared with a group of glycoproteins in human peripheral nerve. The antigen appears to be similar to that recognized by IgM paraproteins associated with a type of neuropathy.