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Related Experiment Videos

Phencyclidine (PCP): some human studies.

S N Pradhan

    Neuroscience and Biobehavioral Reviews
    |January 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Phencyclidine (PCP) intoxication causes dose-dependent effects, including psychosis and impaired physical function. While tolerance develops, psychological dependence and craving for PCP are reported in users.

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    Area of Science:

    • Neuroscience
    • Pharmacology
    • Toxicology

    Background:

    • Phencyclidine (PCP) is a dissociative anesthetic with known psychoactive effects.
    • Previous studies have investigated PCP's impact on human volunteers and illicit users.

    Purpose of the Study:

    • To review and summarize the observed effects of PCP.
    • To elucidate the dose-related nature of PCP's acute and chronic manifestations.

    Main Methods:

    • Review of existing studies and investigator observations on PCP effects.
    • Analysis of data from volunteers and illicit PCP users.

    Main Results:

    • Acute PCP effects are dose-dependent, ranging from sensory disturbances to severe psychosis.
    • High doses induce psychosis, ataxia, and cardiovascular changes; irritability may occur under stress.

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  • Chronic abuse can lead to prolonged toxic psychosis and precipitation of psychotic episodes.

    • Conclusions:

    • PCP exhibits a range of dose-related acute effects and can induce severe psychiatric disturbances.
    • Tolerance to PCP develops, but psychological dependence and craving are significant concerns.