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Related Experiment Videos

Perinatal changes in a digoxin-like immunoreactive substance.

D W Seccombe, M R Pudek, M F Whitfield

    Pediatric Research
    |November 1, 1984
    PubMed
    Summary
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    Neonates possess endogenous digoxin-like immunoreactive substances (DLIS) in their serum. DLIS levels peak in premature infants within the first week of life, correlating inversely with gestational age and birth weight.

    Area of Science:

    • Neonatal physiology
    • Endocrinology
    • Biochemistry

    Background:

    • Endogenous digoxin-like immunoreactive substances (DLIS) are present in infant serum.
    • These substances are distinct from exogenous digoxin administration.
    • Understanding DLIS dynamics is crucial for neonatal care and diagnostics.

    Purpose of the Study:

    • To track serum DLIS concentration changes in premature neonates over the first 14 postnatal days.
    • To investigate the relationship between DLIS levels, gestational age, and birth weight.
    • To determine the origin and developmental changes of DLIS in fetal and neonatal life.

    Main Methods:

    • Serial serum sampling in 24 premature neonates over 14 days.
    • Radioimmunoassay for DLIS concentration measurement.

    Related Experiment Videos

  • Correlation analysis with gestational age and birth weight.

    • Main Results:

    • All infants exhibited measurable DLIS serum levels (>0.6 ng/ml).
    • A peak DLIS concentration was observed in 19/24 infants around postnatal day 4.
    • Peak DLIS levels showed a negative correlation with gestational age and birth weight.
    • Amniotic fluid DLIS increased from 33 weeks gestation to term.
    • Umbilical and maternal serum levels suggested a fetal origin for DLIS.

    Conclusions:

    • Premature neonates have endogenous DLIS with a distinct postnatal peak.
    • DLIS levels are influenced by gestational age and birth weight.
    • DLIS appears to be of fetal origin and its concentration changes during late gestation.