Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gallbladder mechanics in newborn piglets.

G S Kaplan, V K Bhutani, T H Shaffer

    Pediatric Research
    |November 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Biomedical titanium-tantalum alloys for orthopedic implant applications: From manufacturing to biological performance.

    Bioactive materials·2026
    Same author

    Results from the T2K Experiment on Neutrino Mixing Including a New Far Detector μ-like Sample.

    Physical review letters·2026
    Same author

    First Differential Measurement of the Single π^{+} Production Cross Section in Neutrino Neutral-Current Scattering.

    Physical review letters·2025
    Same author

    First Measurement of the Electron-Neutrino Charged-Current Pion Production Cross Section on Carbon with the T2K Near Detector.

    Physical review letters·2025
    Same author

    Towards a home-grown rural health workforce: Evidence from Tasmania, Australia.

    The Australian journal of rural health·2024
    Same author

    Low latency optical-based mode tracking with machine learning deployed on FPGAs on a tokamak.

    The Review of scientific instruments·2024
    Same journal

    Bob Sun: ECI Biocommentary.

    Pediatric research·2026
    Same journal

    The involvement of Anaeroplasma, caproic acid, and interleukins through the brain-gut axis may contribute to IgAV with neurological involvement.

    Pediatric research·2026
    Same journal

    Emerging role of microplastics and nanoplastics in children's health.

    Pediatric research·2026
    Same journal

    Serum cytokine profiling reveals distinct inflammatory signatures in Kawasaki disease and MIS-C and suggests associations with coronary artery lesions.

    Pediatric research·2026
    Same journal

    Protective effects of dexpanthenol on experimental colitis in young rats: modulation of p53/BAX/BCL2 and RIPK1/RIPK3/MLKL signaling with anti-inflammatory activity.

    Pediatric research·2026
    Same journal

    Born under pressure: cardiac adaptation in congenital diaphragmatic hernia.

    Pediatric research·2026
    See all related articles

    Neonatal piglet gallbladders show increased pressure and active tension upon stimulation with histamine and cholecystokinin (CCK). This study characterizes their mechanical properties, offering insights into neonatal bile flow.

    Area of Science:

    • Gastroenterology
    • Physiology
    • Neonatal Medicine

    Background:

    • The mechanical properties of the neonatal gallbladder are not well-characterized.
    • Understanding these properties is crucial for neonatal digestive health and bile flow dynamics.

    Purpose of the Study:

    • To evaluate the mechanical properties of the newborn piglet gallbladder in both stimulated and unstimulated states.
    • To determine pressure-volume relationships, compliance, and active tension.
    • To compare neonatal gallbladder response to adult data.

    Main Methods:

    • Mechanical properties (pressure-volume, compliance, active tension) were measured in 10 newborn piglets (2-7 days old).
    • Agonist stimulation was induced using histamine (25 µg/kg/h) and cholecystokinin (CCK) (60 ng/kg/h).

    Related Experiment Videos

  • Intracholecystic pressure at 50% resting volume was recorded.

    • Main Results:

    • Histamine and CCK significantly increased intracholecystic pressure and active tension (p < 0.05).
    • Pressure increased from 12.4 cm H2O to 18.9 cm H2O (histamine) and 15.5 cm H2O (CCK).
    • Gallbladder compliance showed no significant change after agonist stimulation.

    Conclusions:

    • The neonatal piglet gallbladder exhibits increased active tension and pressure upon stimulation.
    • The lower pressure response compared to adults may contribute to reduced neonatal choledochal bile flow.
    • These findings provide a baseline for neonatal gallbladder mechanical function.