Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nitrogen balance studies during modified fasting.

J G Wechsler, H Wenzel, W Swobodnik

    Postgraduate Medical Journal
    |January 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Antimicrobial resistance of Helicobacter pylori in Germany, 2015 to 2018.

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2019
    Same author

    High-power sampled-grating-based master oscillator power amplifier system with 23.5  nm wavelength tuning around 970  nm.

    Applied optics·2018
    Same author

    [How Reliable are Meta-Analyses? An Appraisal Using the Example of Magnesium Tocolysis].

    Zeitschrift fur Geburtshilfe und Neonatologie·2016
    Same author

    Generation of spectrally stable continuous-wave emission and ns pulses with a peak power of 4 W using a distributed Bragg reflector laser and a ridge-waveguide power amplifier.

    Optics express·2014
    Same author

    Frequency doubling of a passively mode-locked monolithic distributed Bragg reflector diode laser.

    Applied optics·2014
    Same author

    Future waste treatment and energy systems--examples of joint scenarios.

    Waste management (New York, N.Y.)·2013
    Same journal

    Dapagliflozin-induced anaphylactic shock.

    Postgraduate medical journal·2026
    Same journal

    Comparative efficacy of Janus kinase inhibitors in severe alopecia areata: a network meta-analysis based on randomized controlled trials.

    Postgraduate medical journal·2026
    Same journal

    Two cases of toxic epidermal necrolysis with severe ocular involvement treated with adjunctive tofacitinib.

    Postgraduate medical journal·2026
    Same journal

    Diastolic dysfunction and diabetes: the DIADAD study-a retrospective cohort study from Liverpool.

    Postgraduate medical journal·2026
    Same journal

    Care, cash, and proof: forensic accountability for war-related starvation.

    Postgraduate medical journal·2026
    Same journal

    Response to traumatic injuries in polo players in England.

    Postgraduate medical journal·2026
    See all related articles

    Modified fasting for obesity treatment led to significant weight loss with minimal protein depletion. This safe and effective therapy preserved body protein while reducing adipose tissue.

    Area of Science:

    • Nutrition Science
    • Metabolic Disorders
    • Obesity Research

    Background:

    • Liquid protein diets have been linked to harmful protein depletion and fatalities in obese patients.
    • Understanding nitrogen balance is crucial for assessing the safety of weight-loss interventions.

    Purpose of the Study:

    • To evaluate protein losses, measured by urinary nitrogen, during a four-week modified fasting regimen for obesity.
    • To assess the safety and efficacy of modified fasting in a controlled inpatient setting.

    Main Methods:

    • Sixty-one obese patients were randomized into four groups and treated with modified fasting (240-450 kcal/day) for 28 days.
    • Dietary intake was restricted to 33-50 g protein, 1-10 g fat, and 25-45 g carbohydrates daily.
    • Urinary nitrogen losses were monitored to determine nitrogen balance, and body composition changes were analyzed.

    Related Experiment Videos

    Main Results:

    • Patients experienced significant mean weight losses ranging from 11.0 to 13.9 kg over 28 days.
    • The percentage of body protein in weight loss was between 3% and 16%, while adipose tissue constituted 63% to 79%.
    • Nitrogen balance was achieved by the third week, and patient compliance and diet acceptability were excellent with no severe side effects.

    Conclusions:

    • Modified fasting is a highly effective and safe therapeutic approach for managing massive obesity.
    • The regimen promotes substantial fat loss while minimizing detrimental protein depletion.