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[The immunology of psoriasis]
Annales De Dermatologie Et De Syphiligraphie
|January 1, 1976
Summary
Psoriasis is linked to immune system abnormalities, including elevated immunoglobulin A (IgA) and immunoglobulin E (IgE) levels. Further research is needed to understand the precise role of these immune disturbances in psoriasis pathogenesis.
Area of Science:
- Immunology
- Dermatology
Context:
- Psoriasis is a chronic inflammatory skin condition.
- Emerging research indicates significant immune system dysregulation in affected individuals.
Purpose:
- To review and synthesize current findings on immune disturbances associated with psoriasis.
- To highlight specific alterations in humoral and cellular immunity in psoriasis patients.
Summary:
- Elevated serum immunoglobulin A (IgA) and immunoglobulin E (IgE) levels are frequently observed in psoriasis patients.
- Increased salivary IgA and the presence of anti-IgG antibodies and anti-stratum corneum auto-antibodies are noted.
- While cellular immunity appears largely intact, some studies suggest T-lymphocyte deficiencies. High frequencies of specific histocompatibility antigens (BW17, B13, BW38) are associated with psoriasis.
Impact:
- Understanding these immune alterations is crucial for defining the pathogenesis of psoriasis.
- Identifies potential biomarkers and therapeutic targets for psoriasis management.
- Underscores the complex interplay between genetic predisposition and immune responses in psoriasis.