[Evaluation of current preparations and local application in treating peptic ulcer exacerbation]

The effects of modern antiulcerous drugs and local action on the gastric mucosa by endoscopy were studied and compared. The endocrine characteristics of the blood serum were analysed in patients with duodenal ulcer after acute and prolonged use of antiulcerous drugs. The treatment with high doses of phosphalugel and cimetidine was shown to compare very favourably with conventional therapy. Duogastron was found to have a low antiulcerous activity. Cimetidine, duogastron and reglan exerted a marked effect on the endocrine system, which should be taken into consideration on prolonged drug use. Local action on the gastric mucosa by means of endoscopy appeared to be effective in patients resistant to drug therapy.