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Related Experiment Videos

Falsely increased digoxin concentrations in samples from neonates and infants.

J M Hicks, E M Brett

    Therapeutic Drug Monitoring
    |January 1, 1984
    PubMed
    Summary

    Newborn infants may have a digoxin-like substance in their serum. This study found that steroids, not other common substances, mimic this digoxin immunoreactivity, suggesting steroids are the likely cause.

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    Area of Science:

    • Neonatal research
    • Clinical chemistry
    • Pharmacology

    Background:

    • Previous studies suggest a digoxin-like immunoreactive substance in infant serum.
    • The origin and nature of this substance remain unclear.

    Purpose of the Study:

    • To confirm the presence of a digoxin-like immunoreactive substance in neonatal serum.
    • To investigate potential endogenous sources of this substance.

    Main Methods:

    • Evaluation of eight immunoassay kits using serum from non-digoxin-treated newborns and infants.
    • Analysis of correlations between the digoxin-like substance and various neonatal serum components (fatty acids, cholesterol, triglycerides, bilirubin, protein, albumin).
    • Investigation of steroids as potential mimics of digoxin immunoreactivity.

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    Main Results:

    • No correlation was found between the digoxin-like substance and common neonatal serum components.
    • Pooled steroids demonstrated mimicry of digoxin immunoreactivity.
    • Steroids are implicated as the likely endogenous source of the digoxin-like immunoreactive substance.

    Conclusions:

    • The digoxin-like immunoreactive substance in neonatal serum is likely endogenous.
    • Steroids are the probable cause of this observed immunoreactivity.
    • Further research is needed to fully elucidate the role of steroids in neonatal digoxin assays.