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[A new technic for LE cell formation. Preliminary report].

H Gómez-Estrada, P Fernández-Quintero, A Toro-Pérez

    Archivos De Investigacion Medica
    |January 1, 1976
    PubMed
    Summary
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    Disseminated Lupus Erythematosus (DLE) serum is key for forming LE cells, a diagnostic marker. This study confirms DLE serum

    Area of Science:

    • Immunology
    • Hematology

    Background:

    • Lupus erythematosus (LE) is an autoimmune disease.
    • LE cell formation is a diagnostic criterion for LE.

    Purpose of the Study:

    • To investigate the factors involved in LE cell formation.
    • To determine the role of serum and lymphocytes in LE cell formation.

    Main Methods:

    • Blood samples from patients with disseminated Lupus Erythematosus (DLE) and normal subjects were used.
    • Polymorphonuclear cells (PNC) and lymphocytes (L) were incubated with DLE or normal (N) serum.
    • LE cell formation was assessed by microscopy.

    Main Results:

    • LE cells were formed when PNC and L were incubated with DLE serum.

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  • The presence of DLE serum was the determining factor for LE cell formation.
  • LE cell formation occurred in 5-15% of tested samples.

    • Conclusions:

    • DLE serum is essential for LE cell formation.
    • The study provides a simplified method for observing LE cells.
    • This finding aids in understanding LE pathogenesis and diagnosis.