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[Dihydrotachysterol poisoning].

G Müller, E Mendler

    Zeitschrift Fur Die Gesamte Innere Medizin Und Ihre Grenzgebiete
    |October 15, 1984
    PubMed
    Summary

    A 33-year-old female experienced severe intoxication, including hypercalcemia symptoms like vomiting and constipation, after 13 days of dihydrotachysterol (DHT3) therapy. This case highlights potential risks associated with DHT3 and vitamin D3 treatments.

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    Area of Science:

    • Endocrinology
    • Pharmacology
    • Clinical Medicine

    Background:

    • Dihydrotachysterol (DHT3), a vitamin D analog, is used therapeutically.
    • Vitamin D and its analogs can cause toxicity if overdosed.

    Observation:

    • A 33-year-old female developed severe intoxication after 13 days of 30 mg daily dihydrotachysterol (DHT3) therapy.
    • The patient also received calcium gluconate and vitamin D during treatment.
    • Clinical symptoms included adynamia, vomiting, and obstipation, indicative of hypercalcemia syndrome.

    Findings:

    • The observed symptoms are consistent with severe hypercalcemia.
    • The case suggests a potential for toxicity with DHT3 at the administered dosage and duration.
    • Concurrent administration of calcium gluconate and vitamin D may have contributed to the toxicity.

    Implications:

    • This case underscores the importance of careful monitoring during dihydrotachysterol therapy.
    • Understanding the metabolism and efficacy of DHT3 is crucial for safe clinical use.
    • Further research into optimal dosing and potential interactions of vitamin D analogs is warranted.

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