[In vitro studies on the effect of dissolved and undissolved heterologous collagen sponge on human thrombocytes]

Hemostasis in bone-bleeding is difficult. Local haemostatics are often used. We take xenolog collagen-sponge--in bone defects--combined with synthetic apatite, to achieve additional osteoinduction. Mechanism of haemostasis by collagen-sponge is examined. After a detailed discussion of literature in vitro experiments with xenolog collagen-sponge and dissolved collagen-sponge (Pentapharm Braun Melsungen) are reported. While native collagen is an important natural haemostatic agent, this collagen-specific effect is not observed in our experiments, neither in platelets nor in endoplasmatic haemostasis. Regarding clinical eperiences physical effects must be considered as mechanism of haemostasis by xenolog collagen-sponge.