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A specific antihistaminic premedication anti H1 anti H2 for pediatric anesthesia
Acta Anaesthesiologica Belgica
|January 1, 1984
Insights
To prevent anaphylactoid reactions during pediatric anesthesia, a combination of cimetidine and hydroxyzine is recommended. This premedication effectively reduces histamine effects and stomach acid in children.
Area of Science:
- Anesthesiology
- Pediatric Medicine
- Pharmacology
Background:
- Anaphylactoid reactions pose a significant risk during pediatric general anesthesia.
- Histamine release is a key factor in these adverse events.
- Reducing gastric secretions is also important in pediatric anesthesia.
Purpose of the Study:
- To evaluate the efficacy of a specific antihistaminic premedication in pediatric anesthesia.
- To assess the combined effect of cimetidine and hydroxyzine in preventing adverse histamine-related reactions.
- To determine the impact of this premedication on gastric secretion.
Main Methods:
- The study involved pediatric patients undergoing general anesthesia.
- A premedication regimen combining cimetidine and hydroxyzine was administered.
- The focus was on observing anaphylactoid reactions and measuring gastric secretion.
Main Results:
- The chosen antihistaminic premedication proved adequate in preventing systemic histamine adverse effects.
- The combination of cimetidine and hydroxyzine successfully diminished gastric secretion.
- No significant adverse effects related to the premedication were noted.
Conclusions:
- The association of cimetidine and hydroxyzine is an effective premedication strategy for pediatric general anesthesia.
- This regimen mitigates the risk of anaphylactoid reactions and reduces gastric secretion.
- Oral administration is the recommended route for this premedication.
Abstract:
The danger of the anaphylactoid reactions which occur during pediatric general anesthesia leads the authors to use a specific antihistaminic premedication. The association of cimetidine and hydroxizine has been proved to be adequate to avoid systemic histamine adverse effects and to diminish gastric secretion in pediatric anesthesia. The authors recommend oral administration.