Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sample-size calculations in segregation analysis.

F L Wong, J I Rotter

    American Journal of Human Genetics
    |November 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Genome-wide analysis of mitochondrial DNA copy number reveals loci implicated in nucleotide metabolism, platelet activation, and megakaryocyte proliferation.

    Human genetics·2021
    Same author

    Genome-wide meta-analysis of variant-by-diuretic interactions as modulators of lipid traits in persons of European and African ancestry.

    The pharmacogenomics journal·2019
    Same author

    Bidirectional Mendelian randomization to explore the causal relationships between body mass index and polycystic ovary syndrome.

    Human reproduction (Oxford, England)·2018
    Same author

    Pharmacogenomics study of thiazide diuretics and QT interval in multi-ethnic populations: the cohorts for heart and aging research in genomic epidemiology.

    The pharmacogenomics journal·2017
    Same author

    Large-scale pharmacogenomic study of sulfonylureas and the QT, JT and QRS intervals: CHARGE Pharmacogenomics Working Group.

    The pharmacogenomics journal·2016
    Same author

    Generalization and fine mapping of European ancestry-based central adiposity variants in African ancestry populations.

    International journal of obesity (2005)·2016
    Same journal

    Bi-allelic missense variants in human GPN2 result in Perrault syndrome.

    American journal of human genetics·2026
    Same journal

    Integrative analysis of gastric tissue transcriptomes and gastric cancer GWAS implicates candidate susceptibility genes.

    American journal of human genetics·2026
    Same journal

    A transparent and generalizable deep-learning framework for genomic ancestry prediction.

    American journal of human genetics·2026
    Same journal

    Data-driven RNA phenotyping captures genetically regulated dimensions of the transcriptome.

    American journal of human genetics·2026
    Same journal

    Linkage disequilibrium and allelic heterogeneity explain variation in coronary artery disease risk at 9p21 across populations and reduced effect in Africans.

    American journal of human genetics·2026
    Same journal

    Genome-wide association study and predictors of neonatal blood cell traits in Hispanic newborns.

    American journal of human genetics·2026
    See all related articles

    This study provides essential sample-size tables for geneticists to determine the number of families needed for segregation analysis. These tables help optimize study design and reduce costs in genetic epidemiology research.

    Area of Science:

    • Genetics
    • Epidemiology
    • Biostatistics

    Background:

    • Segregation analysis in nuclear families is a primary method for determining trait inheritance.
    • Existing literature lacks comprehensive tables for required sample sizes in segregation analysis.
    • Accurate sample size estimation is crucial for the statistical power and efficiency of genetic studies.

    Purpose of the Study:

    • To develop and present sample-size tables for segregation analysis.
    • To aid researchers in designing genetic epidemiology studies with adequate statistical power.
    • To facilitate cost-effective planning of genetic research by defining necessary sample sizes.

    Main Methods:

    • Utilized the asymptotic variance of the maximum likelihood estimate for the segregation ratio.

    Related Experiment Videos

  • Employed normal approximation for two-sided hypothesis testing.
  • Calculated minimum sample sizes for various null hypotheses (1/4, 1/2), alternative values (.05-.80), significance level (0.05), power (0.8), ascertainment probabilities (0-1.0), and sibship sizes (2-7).

    • Main Results:

    • Developed comprehensive tables detailing required sample sizes for segregation analysis.
    • Demonstrated a complex interplay between null/alternative hypotheses, ascertainment probability, and sibship size in sample size determination.
    • Results highlight the variability in sample size requirements based on specific genetic parameters.

    Conclusions:

    • The generated tables provide a valuable resource for researchers conducting segregation analysis.
    • These tables will assist in the appropriate design and cost assessment of future genetic epidemiology studies.
    • Accurate sample size planning is critical for the successful outcome of genetic trait inheritance studies.