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[Morphine concentrations in serum in need-controlled peridural morphine infusion]
Anasthesie, Intensivtherapie, Notfallmedizin
|October 1, 1984
Summary
Intensive care patients required significantly more morphine for postoperative pain relief than non-intubated patients. Pharmacokinetics of morphine differed between groups, with higher, later, and longer plateau concentrations of metabolized morphine in intensive care patients.
Area of Science:
- Anesthesiology
- Pharmacology
- Intensive Care Medicine
Context:
- Postoperative pain management after abdominal or thoracoabdominal surgery.
- Epidural on-demand morphine infusion used for pain relief.
- Comparison between non-intubated patients (Group I) and artificially ventilated intensive care patients (Group II).
Purpose:
- To evaluate and compare morphine consumption and pharmacokinetics in non-intubated versus intensive care patients receiving epidural on-demand morphine infusion.
- To analyze differences in serum concentrations of free and metabolized morphine.
- To assess the impact of ventilation status on morphine pharmacokinetics.
Summary:
- 48 patients received epidural morphine post-surgery; 34 non-intubated (Group I) and 14 ventilated (Group II).
- Group II consumed significantly more morphine (34.0 mg) than Group I (6.4 mg).
- Pharmacokinetics varied: Group II showed increased free morphine and higher, later, longer plateau concentrations of metabolized morphine.
Impact:
- Highlights increased morphine requirements in mechanically ventilated intensive care patients.
- Demonstrates distinct morphine pharmacokinetics influenced by ventilation status.
- Informs optimized pain management strategies for critically ill surgical patients.