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Related Experiment Videos

External quality assessment of quantitative urinary analysis.

E F Legg, A E Hurrell

    Annals of Clinical Biochemistry
    |November 1, 1984
    PubMed
    Summary

    A quality assessment scheme evaluated 13 labs on 11 urinary analyses. Urinary protein assays showed the most variability between labs, highlighting a need for improved standardization in clinical chemistry assessments.

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    Area of Science:

    • Clinical Chemistry
    • Laboratory Medicine
    • Analytical Toxicology

    Background:

    • External quality assessment (EQA) is crucial for maintaining laboratory performance standards.
    • Standardized urinary analysis is essential for accurate patient diagnosis and monitoring.

    Purpose of the Study:

    • To assess the performance of 13 clinical chemistry laboratories in urinary analysis.
    • To identify analytical variability in specific urinary analytes and creatinine clearance estimation.

    Main Methods:

    • An external quality-assessment scheme was implemented.
    • Participating laboratories analyzed 11 common urinary analytes: calcium, chloride, creatinine, glucose, osmolality, phosphate, potassium, protein, sodium, urate, and urea.
    • Creatinine clearance was also estimated.

    Main Results:

    • Inter-laboratory imprecision was greatest for urinary protein assays.
    • Variability was observed across other tested urinary analytes and creatinine clearance estimations.
    • The study provided comparative data against similar international quality assessment schemes.

    Conclusions:

    • Urinary protein assays represent a significant challenge for inter-laboratory consistency.
    • The findings underscore the need for enhanced standardization and quality control in clinical chemistry laboratory practices for urinary analysis.
    • Comparative analysis with other schemes provides valuable insights into global laboratory performance.

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