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Related Experiment Videos

Gastric candidiasis.

P E Gillespie, P H Green, P J Barrett

    The Medical Journal of Australia
    |February 25, 1978
    PubMed
    Summary
    This summary is machine-generated.

    A severe gastric Candida infection occurred in a patient with rheumatoid arthritis treated with prednisone. Antifungal therapy led to rapid symptom resolution, highlighting the need to consider gastric candidiasis in immunocompromised individuals.

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    Area of Science:

    • Gastroenterology
    • Infectious Diseases
    • Mycology

    Background:

    • Rheumatoid arthritis (RA) treatment often involves immunosuppressive medications like prednisone.
    • Previous gastrointestinal surgery, such as Polya partial gastrectomy, can alter gastric anatomy and physiology.
    • Prednisone use can increase the risk of opportunistic infections, including fungal infections.

    Observation:

    • A 60-year-old male patient with RA on prednisone developed severe, symptomatic stomal gastritis.
    • Endoscopic examination revealed lesions resembling Candida infection, typically seen in the esophagus.
    • Candida albicans was successfully cultured from biopsy specimens of the gastric lesion.

    Findings:

    • The patient's stomal gastritis and symptoms resolved promptly following oral antifungal therapy.

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  • The findings suggest a primary gastric candidiasis infection.
  • Successful treatment with oral antifungals confirms the diagnosis and efficacy of treatment.

    • Implications:

    • Primary gastric candidiasis should be considered in the differential diagnosis of upper gastrointestinal symptoms in immunocompromised patients.
    • This case underscores the importance of recognizing fungal infections in specific patient populations.
    • Early diagnosis and treatment of gastric candidiasis can prevent severe complications and improve patient outcomes.