Screening for new compounds with antiherpes activity

A number of compounds have been tested for antiherpes activity. Actinobolin, amicetin, carrageenan, laspartomycin, megalomycin C, pleuromutilin, suramin and tetracenomycin C showed significant protection of HeLa cell monolayers infected with herpes simplex virus type 1. The action of these new antiherpes compounds was compared with those antiherpes agents that have been described previously. Actinobolin, amicetin and tetracenomycin C were also active against viruses other than herpes simplex.