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Related Experiment Videos

"Hemicrania continua". An indomethacin responsive headache. II. Autonomic function studies.

O Sjaastad, E L Spierings, C Saunte

    Cephalalgia : an International Journal of Headache
    |December 1, 1984
    PubMed
    Summary

    Hemicrania continua, a unilateral headache, shows unique pupillometry changes corrected by indomethacin. This autonomic finding distinguishes it from other indomethacin-responsive headaches.

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    Area of Science:

    • Neurology
    • Autonomic Neuroscience

    Background:

    • Hemicrania continua is a newly described unilateral headache.
    • Indomethacin is known to abort this headache type.

    Purpose of the Study:

    • To investigate autonomic parameters in hemicrania continua.
    • To differentiate hemicrania continua from other headache types using pupillometry.

    Main Methods:

    • Studied autonomic parameters in two patients with hemicrania continua.
    • Performed pupillometry before and after tyramine instillation.
    • Assessed the effect of indomethacin medication.

    Main Results:

    • Patients presented with isocoria (equal pupils) when untreated.
    • Bilateral tyramine instillation caused anisocoria (unequal pupils), with the smaller pupil on the headache side.

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  • Indomethacin treatment normalized pupillometry.

    • Conclusions:

    • Pupillometric findings in hemicrania continua are distinct.
    • These autonomic changes suggest a unique pathophysiology.
    • Hemicrania continua differs from chronic paroxysmal hemicrania based on these pupillometric anomalies.