Related Experiment Video
Updated: May 3, 2026
07:03
Standardized Colon Ascendens Stent Peritonitis in Rats - a Simple, Feasible Animal Model to Induce Septic Acute Kidney Injury
Published on: February 15, 2022
1.3K
Is renal involvement a prognostic parameter in patients with infective endocarditis?
European Heart Journal
|October 1, 1984
Summary
Renal involvement, defined as kidney damage with proteinuria and hematuria, affects 50% of infective endocarditis patients. This condition significantly increases mortality risk but often improves with treatment.
Area of Science:
- Nephrology
- Cardiology
- Infectious Diseases
Background:
- Infective endocarditis (IE) is a serious infection affecting heart valves.
- Renal involvement (RI) is a potential complication of IE, but its prevalence and prognostic significance require further elucidation.
Purpose of the Study:
- To investigate the prevalence and characteristics of renal involvement in patients with infective endocarditis.
- To assess the impact of renal involvement on mortality and long-term renal function following IE treatment.
Main Methods:
- Studied 80 patients diagnosed with infective endocarditis.
- Defined renal involvement as proteinuria (>150 mg/24h) with hematuria or impaired glomerular filtration rate.
- Quantitatively measured proteinuria and analyzed patterns using SDS-polyacrylamide-gel electrophoresis (SDS-PAGE).
Main Results:
- Renal involvement was identified in 50% of patients (40/80), with proteinuria ranging from 150 to 8000 mg/24h.
- SDS-PAGE indicated tubular (17 patients), glomerular (6 patients), or glomerulo-tubular (17 patients) patterns.
- Mortality rate was significantly higher in patients with RI (40%) compared to those without (7.5%).
Conclusions:
- Renal involvement is a common complication of infective endocarditis with significant prognostic implications.
- Successful treatment of IE can lead to complete normalization of renal function in a majority of affected patients.
- Early identification and management of renal involvement in IE are crucial for improving patient outcomes.
Related Concept Videos
01:25Endocarditis I: Introduction
873
Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
873
01:25Endocarditis II: Clinical Features of Infective Endocarditis
929
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
929
01:18Endocarditis III: Medical Management
360
Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
360
01:29Endocarditis IV: Nursing Management
630
Infective endocarditis (IE) is a chronic infection of the heart's endocardium, primarily affecting the heart valves. A detailed nursing assessment for a patient with IE involves collecting subjective and objective data to ensure an accurate diagnosis and timely intervention.Subjective DataThe nurse gathers information about the patient's symptoms and complaints during the subjective assessment. Patients with infective endocarditis often report non-specific symptoms that can mimic other...
630
01:22Acute Kidney Injury I: Introduction
1.4K
Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
1.4K
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
559
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
559