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Prostatitis: are the gram-positive organisms pathogenic?

J F Jiménez-Cruz, M Martínez Ferrer, A Allona Almagro

    European Urology
    |January 1, 1984
    PubMed
    Summary
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    Gram-positive bacteria frequently colonize the urethra and prostatic ducts in men. However, these bacteria do not appear to cause actual prostatic infections, challenging previous assumptions about their role.

    Area of Science:

    • Urology
    • Microbiology
    • Infectious Diseases

    Background:

    • Prostatitis and related symptoms like sterility and sexual impairment are common urological issues.
    • The role of Gram-positive bacteria in prostatic infections has been previously suggested.
    • Accurate diagnosis of prostatic infection is crucial for effective treatment.

    Purpose of the Study:

    • To investigate the prevalence and significance of Gram-positive bacterial colonization in the male genitourinary tract.
    • To determine if isolated Gram-positive bacteria are indicative of true prostatic infection.
    • To re-evaluate diagnostic criteria for bacterial prostatitis.

    Main Methods:

    • Collected urine samples (first void and midstream), prostatic secretions, and semen from 268 patients.

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  • Performed bacterial cultures and exfoliative cytology on all collected samples.
  • Utilized Meares and Stamey criteria for assessing significant bacterial cultures.
  • Re-evaluated findings in patients without prior antibiotic therapy.
  • Main Results:

    • Gram-positive bacteria were isolated in 160 out of 268 patients (59.7%).
    • Significant cultures according to Meares and Stamey criteria were found in 111 patients (69.3% of those with Gram-positive isolates).
    • Results could not be confirmed when the study was repeated without previous therapy, indicating transient colonization.

    Conclusions:

    • Gram-positive bacteria commonly colonize the urethra and/or prostatic ducts.
    • The presence of Gram-positive bacteria in cultures does not necessarily indicate active prostatic infection.
    • Previous therapeutic interventions may influence bacterial presence and diagnostic outcomes.