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Erythrapheresis compared with placebo apheresis in patients with polycythaemia secondary to hypoxic lung disease
Abstract:
We have assessed the effects of erythrapheresis, a method of isovolaemic haemodilution, and placebo apheresis in 10 patients with polycythaemia secondary to chronic hypoxic lung disease (Mean PaO2 7.2kPa (54 mm Hg]. The mean packed cell volume decreased from 0.60 to 0.48, with significant decreases in blood viscosity at both high and low shear rates (p less than 0.001). The 6-min walking distance improved after erythrapheresis with no significant placebo effect of the procedure compared to control subjects (p less than 0.01). Erythrapheresis is a safe procedure for packed cell volume reduction. It is associated with clinical improvement and there is no demonstrable placebo effect on exercise tolerance.
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Erythropoiesis
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