Experimental studies on mice challenged intracerebrally with Pseudomonas aeruginosa

Intact or immunodepressed mice of different strains were challenged with Pseudomonas aeruginosa cells by the peritoneal or intracerebral route, in order to establish experimental models which may mimic the clinical conditions of compromised hosts experiencing local or systemic invasion by the opportunistic pathogen. The possible role played by host sensitization alone or in combination with chemotherapy was also studied.