Sunscreen agents induce DNA repair activity in mouse embryo fibroblasts

In this study we have examined the DNA repair profile and cell survival of mouse 10T1/2 fibroblasts after exposure to UVC (254 nm) and the sunscreen agents p-aminobenzoic acid, dihydroxyacetone, Escalol 506, and Escalol 507. DNA repair was monitored by BrdUrd photolysis and alkaline gradient sedimentation. The results indicate that in the treatment protocol utilized, Escalol 506 and Escalol 507 were capable of inducing DNA repair activity in the absence of UVC. Data are also presented which illustrate the protective effect preincubation with Escalol 507 has upon cell survival.