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Updated: Aug 10, 2026

Microdialysis of Ethanol During Operant Ethanol Self-administration and Ethanol Determination by Gas Chromatography
Published on: September 5, 2012
Inhibition of methadone and phenobarbital percutaneous absorption by parenterally administered ethanol
Abstract:
Four hours after the topical administration of either aqueous methadone hydrochloride or sodium phenobarbital to hairless (SKH, hr-1/hr-1) mice, the mean drug concentration in liver was significantly lower in ethanol-treated mice than in control animals that had received only water (methadone study, p less than 0.01; phenobarbital study, p less than 0.02). No statistically significant difference was noted between the mean concentrations for test and control mice when either methadone or phenobarbital were given by intraperitoneal injection instead of topically, suggesting that ethanol inhibits the percutaneous absorption of these drugs in vivo.
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