Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antidepressant tachyphylaxis.

J Lieb, A Balter

    Medical Hypotheses
    |November 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Tachyphylaxis, or diminishing effectiveness, can occur with antidepressants, lithium, and ECT. This phenomenon may be more common in mood disorder treatments than currently recognized.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Vestibular self-motion perception in a patient with bilateral thalamic infarction.

    Journal of neurology·2025
    Same author

    Rapid point-of-care detection of SARS-CoV-2 infection in exhaled breath using ion mobility spectrometry: a pilot study.

    European journal of medical research·2023
    Same author

    Systematic Radiation Dose Reduction in Cervical Spine CT of Human Cadaveric Specimens: How Low Can We Go?

    AJNR. American journal of neuroradiology·2017
    Same author

    [Osler's disease].

    Der Radiologe·2013
    Same author

    Fluorescence probes of viscosity: A comparative study of the fluorescence anisotropy decay of perylene and 3,9-dibromoperylene in glycerol.

    Journal of fluorescence·2013
    Same author

    A statistical model of steady-state solvatochromism.

    Journal of fluorescence·2013
    Same journal

    Calcitonin Gene-Related Peptide-Induced Central Sensitization: A Hypothesis for Long COVID Symptoms.

    Medical hypotheses·2026
    Same journal

    Subclinical mastitis during lactation: a modifiable risk factor for breast cancer?

    Medical hypotheses·2025
    Same journal

    The Role of Hemispheric Sensory Shifts: Impacts on Stretch Reflex and Motor Plasticity Post-Stroke.

    Medical hypotheses·2025
    Same journal

    Neuron-Targeted Exosome Therapy: A Novel Approach for Treating Cardiogenic Dementia via RyR2 Inhibition.

    Medical hypotheses·2025
    Same journal

    How the Somatosensory System Adapts to the Motor Change in Stroke: A Hemispheric Shift?

    Medical hypotheses·2024
    Same journal

    Unstable Plaque is a Treatable Cause of Cognitive Decline.

    Medical hypotheses·2024
    See all related articles

    Area of Science:

    • Psychiatry
    • Pharmacology
    • Neuroscience

    Background:

    • Mood-regulating therapies, including antidepressants, lithium, and electroconvulsive therapy (ECT), are mainstays in treating mood disorders.
    • Initial treatment response is often positive, but long-term efficacy can be variable.

    Observation:

    • Eleven patients experienced tachyphylaxis, a rapid decrease in drug response, to antidepressants, lithium, or ECT.
    • These cases represent a subset of patients observed with a loss of initial therapeutic benefit.

    Findings:

    • Tachyphylaxis is a significant clinical observation in mood disorder management.
    • The sustained efficacy of common psychotropic medications and ECT can be compromised over time.

    Implications:

    Related Experiment Videos

    • Further systematic research is needed to quantify the prevalence of tachyphylaxis in antidepressant and other mood-regulating therapies.
    • Understanding and addressing tachyphylaxis is crucial for optimizing long-term patient outcomes in mood disorder treatment.