Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neuroimaging in multiple sclerosis.

J H Noseworthy, D W Paty, G C Ebers

    Neurologic Clinics
    |November 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Computed Tomography (CT) and Nuclear Magnetic Resonance Imaging (NMRI) are crucial for diagnosing multiple sclerosis (MS). CT detects atrophy and lesions, while NMRI is more sensitive for active inflammation and cumulative disease effects.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The relationship of age with the clinical phenotype in multiple sclerosis.

    Multiple sclerosis (Houndmills, Basingstoke, England)·2016
    Same author

    Review: the role of vitamin D in nervous system health and disease.

    Neuropathology and applied neurobiology·2013
    Same author

    fMRI and corpus callosum relationships in monozygotic twins discordant for handedness.

    Brain structure & function·2012
    Same author

    Survival in MS: a randomized cohort study 21 years after the start of the pivotal IFNβ-1b trial.

    Neurology·2012
    Same author

    Age and disability accumulation in multiple sclerosis.

    Neurology·2011
    Same author

    HLA B*44: protective effects in MS susceptibility and MRI outcome measures.

    Neurology·2011

    Area of Science:

    • Neurology
    • Radiology
    • Neuroimaging

    Background:

    • Multiple Sclerosis (MS) diagnosis relies on neuroimaging.
    • Conventional CT scans were early tools for MS assessment.
    • Common CT findings include cerebral atrophy, hypodense foci, and contrast-enhancing lesions.

    Purpose of the Study:

    • To evaluate the utility of conventional CT and NMRI in assessing multiple sclerosis.
    • To understand the significance of CT and NMRI findings in relation to MS pathology and disease activity.

    Main Methods:

    • Review of conventional CT studies in multiple sclerosis patients.
    • Analysis of contrast-enhanced CT and serial CT studies.
    • Evaluation of Nuclear Magnetic Resonance Imaging (NMRI) findings in MS.

    Related Experiment Videos

  • Correlation of imaging findings with clinical disease activity and pathology.

    • Main Results:

    • CT abnormalities include cerebral atrophy, hypodense lesions (recent or remote demyelination), and contrast-enhancing lesions indicating active inflammation.
    • High-volume delayed CT studies enhance detection of abnormalities, especially during clinical disease activity.
    • NMRI is highly sensitive for detecting MS lesions, particularly in the posterior fossa.
    • NMRI lesions often persist, suggesting cumulative effects of past and present disease activity.

    Conclusions:

    • CT and NMRI are valuable neuroimaging modalities for multiple sclerosis assessment.
    • Contrast-enhancing lesions on CT signify active inflammation.
    • NMRI offers superior sensitivity for MS lesion detection and monitoring cumulative disease burden.