Lymphomatoid granulomatosis with cerebral involvement

We report the case of a 26-year-old man who suffered from lymphomatoid granulomatosis. The light microscopical features of a biopsy from involved cerebral tissue are described and for the first time the cytological findings on a brain smear are illustrated. The results of immunological and electronmicroscopical investigations are consistent with the suggestion that this disease may be a disorder of T lymphocytes. It is suggested that the smear technique may be used to confirm the presence of cerebral disease in patients with an established diagnosis, and to investigate suspected patients who present with extrapulmonary manifestations.