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Aortic recognition sites for serotonin (5HT) are coupled to phospholipase C and modulate phosphatidylinositol
Neuropharmacology
|October 1, 1984
Abstract:
The 5HT-mediated contraction of rat thoracic aorta is competitively blocked by the specific receptor antagonist 5HT2 ketanserin. In this tissue the addition of 5HT activated the turnover of 3H-phosphatidylinositol in a ketanserin-reversible fashion. These 5HT2 recognition sites appear to be coupled to a phospholipase C mediated cleavage of phosphatidylinositol.