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Related Experiment Videos

Cross adaption between stress and cold in rats.

A Kuroshima, Y Habara, A Uehara

    Pflugers Archiv : European Journal of Physiology
    |December 1, 1984
    PubMed
    Summary

    Repeated stress enhances cold tolerance in rats by boosting nonshivering thermogenesis. This adaptation involves increased brown adipose tissue (BAT) function, crucial for maintaining body temperature.

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    Area of Science:

    • Physiology
    • Endocrinology
    • Stress Physiology

    Background:

    • Chronic stress impacts physiological adaptations.
    • Cold tolerance is essential for survival in low-temperature environments.
    • Brown adipose tissue (BAT) plays a key role in thermogenesis.

    Purpose of the Study:

    • To investigate the effects of repetitive immobilization stress on cold tolerance in rats.
    • To explore the role of nonshivering thermogenesis and brown adipose tissue (BAT) in stress-induced adaptations.
    • To examine hormonal changes associated with stress and cold exposure.

    Main Methods:

    • Male Wistar rats were subjected to 3-hour daily immobilization stress for 1-8 weeks.
    • Cold tolerance was assessed by measuring colonic temperature at -5°C.
    • Nonshivering thermogenesis was evaluated by noradrenaline-induced oxygen consumption.
    • Brown adipose tissue (BAT) weight, protein content, and mitochondrial packing were analyzed.
    • Plasma levels of insulin, glucagon, thyroxine, and triiodothyronine were measured.

    Main Results:

    • Stressed rats exhibited reduced body weight gain but improved cold tolerance.
    • Nonshivering thermogenesis was significantly potentiated in stressed rats.
    • Interscapular BAT showed increased weight, protein content, and mitochondrial density.
    • Plasma insulin and thyroxine levels decreased in stressed rats.
    • Removal of BAT abolished the enhanced cold tolerance and nonshivering thermogenesis.

    Conclusions:

    • Repetitive stress induces cross-adaptation to cold through enhanced nonshivering thermogenesis.
    • Stimulation of brown adipose tissue (BAT) function is a key mechanism in this adaptation.
    • Stress-induced changes in hormonal profiles may contribute to altered thermoregulation.

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