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The human placenta does not contain lipofuscin pigment.

M Haigh, L E Chawner, H Fox

    Placenta
    |September 1, 1984
    PubMed
    Summary

    Autofluorescent granules in the human placenta are actually lipid droplets, not lipofuscin pigment. These granules are most prominent in the first trimester of pregnancy.

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    Area of Science:

    • Human placental biology
    • Cellular ultrastructure
    • Biochemistry

    Background:

    • Autofluorescent granules have been reported in the placental villous syncytiotrophoblast.
    • Previous identifications suggested these granules were lipofuscin pigment.

    Purpose of the Study:

    • To characterize the nature of autofluorescent granules in the human placenta.
    • To determine if these granules represent lipofuscin pigment.

    Main Methods:

    • Electron microscopy of placental villi.
    • Histochemical staining techniques.
    • Microscopic examination of granule morphology and staining characteristics.

    Main Results:

    • Autofluorescent granules are most prominent in the first-trimester placenta.
    • These granules exhibit distinct size and hue compared to classical lipofuscin.
    • Electron microscopy revealed the granules to be syncytial lipid droplets.
    • Staining characteristics differed from those of lipofuscin.

    Conclusions:

    • The autofluorescent granules in the syncytiotrophoblast are lipid droplets, not lipofuscin pigment.
    • Previous reports of lipofuscin in the placenta are considered unfounded based on these findings.

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