The evaluation of the carcinogenicity of environmental substances

A review of the current status of carcinogenicity assessment leads to a number of observations that raise specific questions about the conduct and techniques of these bioassays. An approach is suggested that avoids many of the scientific controversies associated with the use of excessively high doses that cause secondary toxicity, leading to a promoter-like effect. Recommendations are made to utilize toxicokinetic data that relate metabolic characteristics of a chemical to its potential carcinogenic effects.