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[Myelomatous bone. Histomorphometric study and therapeutic effects].

S A Charhon, A Valentin-Opran, C Edouard

    Revue Du Rhumatisme Et Des Maladies Osteo-Articulaires
    |December 15, 1984
    PubMed
    Summary

    Multiple myeloma patients show increased bone resorption due to elevated osteoclasts, despite active bone formation. Chemotherapy does not alter this osteoclastic activity, supporting the use of anti-resorptive agents.

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    Area of Science:

    • Histopathology
    • Oncology
    • Bone Biology

    Context:

    • Multiple myeloma frequently causes bone lesions.
    • Understanding the histological basis of these bone changes is crucial for treatment.

    Purpose:

    • To quantitatively evaluate bony changes in multiple myeloma using transiliac bone biopsies.
    • To compare histological findings between chemotherapy-treated and untreated patients.

    Summary:

    • Histological analysis of 118 bone biopsies revealed increased osteoclastic resorption and elevated osteoclast numbers in myeloma-invaded bone areas.
    • While tetracycline binding indicated active bone formation, reduced osteoid thickness and calcification rates suggested decreased osteoblastic activity.
    • Trabecular bone volume was not significantly reduced, but plasmacyte infiltration varied.

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  • Chemotherapy did not alter increased osteoclastic activity in invaded zones.

    • Impact:

    • Findings support the use of anti-osteoclastic agents, such as diphosphonates, to manage bone disease in multiple myeloma.
    • Highlights the persistent osteoclastic activity despite chemotherapy, indicating a target for therapeutic intervention.