Treatment of gonorrhea with single-dose thiamphenicol

This study was undertaken to determine the effectiveness of a single 2.5-g dose of thiamphenicol as therapy for gonococcal infection and to compare the results obtained in a limited group of male and female patients to those reported by other investigators. Diagnosis was determined by direct microscopy and culture. Cure was defined as the abolishment of symptoms in males and disappearance of microscopic evidence of gonococci in females. Follow-up examination was not performed. Of the 28 males and five females treated, 30 (90.9%) experienced relief of symptoms according to the criteria given above. These results are compatible with those reported for other drug regimens.