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Ascorbic acid effect on ethanol sensitivity via possible dopaminergic mediation.

J Yanai, R H Fishman, L Mittleman

    Substance and Alcohol Actions/Misuse
    |January 1, 1984
    PubMed
    Summary
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    High doses of ascorbic acid (vitamin C) significantly prolonged ethanol-induced sleep time in mice. Ascorbic acid also reduced apomorphine-induced activity, suggesting it may increase brain sensitivity to alcohol by affecting dopamine receptors.

    Area of Science:

    • Neuroscience
    • Pharmacology

    Background:

    • Ethanol (alcohol) consumption can lead to prolonged sleep and impaired motor activity.
    • Ascorbic acid, also known as vitamin C, is a common antioxidant with potential neuroactive properties.

    Purpose of the Study:

    • To investigate the effects of ascorbic acid on ethanol-induced sleep time and apomorphine-induced locomotor activity in mice.
    • To explore the potential role of dopamine receptor activity in mediating these effects.

    Main Methods:

    • Mice were administered varying doses of ascorbic acid (0-1720 mg/kg) before testing for ethanol-induced sleep time (3.5 g/kg).
    • Brain ethanol levels were measured upon awakening.
    • Locomotor activity was assessed after apomorphine (3 mg/kg) injection in mice pre-treated with ascorbic acid.

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    Main Results:

    • Ascorbic acid doses above 215 mg/kg significantly increased ethanol sleep time, with a 210% augmentation at the highest dose.
    • Brain ethanol levels upon awakening were reduced by ascorbic acid, notably at 1720 mg/kg.
    • Ascorbic acid dose-dependently decreased apomorphine-induced locomotor activity, completely inhibiting it at the highest dose.

    Conclusions:

    • Ascorbic acid potentiates the effects of ethanol, increasing sleep duration.
    • The observed effects suggest ascorbic acid may enhance ethanol's impact by reducing dopamine receptor activity.
    • Further research is warranted to elucidate the precise mechanisms of ascorbic acid's neuropharmacological actions.