[Cluster analysis of the classification of disseminated lupus erythematosus]

Using a grouping method the disease homogeneity within a group of 59 patients with systemic lupus erythematosus was studied. The mean observation period was 8 years and 10 months. By using a cluster analysis, the total group of patients could be divided into two subgroups which differed clearly in their symptomatology. One subgroup showed a higher incidence of hypertension, severe anaemia, oral ulceration, elevated serum creatinine values, and proteinuria. All 8 deaths occurred in this group. The second group was characterized by a more benign course of disease, a notably decreased incidence of symptoms characteristic for the first subgroup, and no deaths.