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The effect of phenylephrine on the accommodative process in man.

Acta Ophthalmologica

|December 1, 1984

Summary

Phenylephrine eye drops reduce accommodation in healthy adults, with effects increasing with concentration. In children, phenylephrine did not significantly alter atropine

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Area of Science:

Ophthalmology
Pharmacology

Background:

Phenylephrine is a sympathomimetic agent used in ophthalmology.
Its effects on accommodation and interaction with cycloplegics require further elucidation.

Purpose of the Study:

To investigate the dose-dependent effect of phenylephrine eye drops on accommodation in healthy adults.
To evaluate the impact of phenylephrine on the cycloplegic effect of atropine in children.

Main Methods:

Double-blind study in 10 healthy volunteers measuring accommodation before and after phenylephrine instillation (0.1%, 1.0%, 10%).
Randomized trial in 20 children (3-6 years) assessing atropine's cycloplegic effect with or without phenylephrine.

Main Results:

Accommodation decreased exponentially with increasing phenylephrine concentration.
A 10% phenylephrine drop reduced accommodation by an average of 3 dioptres.
Phenylephrine did not significantly alter atropine's cycloplegic effect in children, though a slight, non-significant hypermetropic shift was observed in some.

Conclusions:

Phenylephrine eye drops induce a concentration-dependent decrease in accommodation.
Phenylephrine does not significantly potentiate the cycloplegic effect of atropine in young children.

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