Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Long-lasting neurological sequelae after lithium intoxication.

M Schou

    Acta Psychiatrica Scandinavica
    |December 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Return to work after COVID-19 infection - A Danish nationwide registry study.

    Public health·2022
    Same author

    Increased long-term risk of heart failure and other adverse cardiac outcomes in dermatomyositis and polymyositis: Insights from a nationwide cohort.

    Journal of internal medicine·2021
    Same author

    Incidence of acute myocardial infarction-related cardiogenic shock during corona virus disease 19 (COVID-19) pandemic.

    International journal of cardiology. Heart & vasculature·2020
    Same author

    Preheart failure comorbidities and impact on prognosis in heart failure patients: a nationwide study.

    Journal of internal medicine·2020
    Same author

    Low N-terminal pro-brain natriuretic peptide levels are associated with non-alcoholic fatty liver disease in patients with type 2 diabetes.

    Diabetes & metabolism·2018
    Same author

    Prevalence of serum anti-neuronal autoantibodies in patients admitted to acute psychiatric care.

    Psychological medicine·2016

    Lithium intoxication can cause lasting neurological damage, including cerebellar issues and peripheral neuropathy. Early rehabilitation may aid recovery, but prevention strategies are crucial.

    Area of Science:

    • Neuroscience
    • Clinical Pharmacology

    Background:

    • Lithium is a common mood stabilizer with a narrow therapeutic index.
    • Lithium intoxication can lead to severe and persistent neurological complications.
    • Understanding the factors contributing to intoxication and sequelae is vital for patient safety.

    Purpose of the Study:

    • To investigate the development and progression of long-term neurological sequelae following lithium intoxication.
    • To identify circumstances that precipitate lithium intoxication.
    • To discuss preventative measures and guidelines.

    Main Methods:

    • Combined literature review and correspondence follow-up.
    • Analysis of clinical data from 40 patients with lithium intoxication.
    • Examination of precipitating factors and neurological outcomes.

    Related Experiment Videos

    Main Results:

    • Neurological sequelae, primarily cerebellar dysfunction (ataxia, scanning speech), occurred after acute lithium intoxication.
    • Peripheral neuropathy and other brain region involvement were also observed.
    • Improvement was noted in some patients within 6-12 months with rehabilitation.

    Conclusions:

    • Lithium intoxication can result in significant and lasting neurological deficits.
    • Various factors, including somatic illness, medication interactions, and dosing errors, can precipitate intoxication.
    • Implementing preventative strategies and clear guidelines is essential to mitigate risks.