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Amiodarone in atrial fibrillation.
Acta Medica Scandinavica
|January 1, 1984
Summary
Oral amiodarone effectively manages atrial fibrillation by preventing episodes and recurrence, and can also control ventricular rate. This study shows amiodarone
Area of Science:
- Cardiology
- Pharmacology
Background:
- Atrial fibrillation is a common arrhythmia.
- Patients often have refractory arrhythmias to existing treatments.
Purpose of the Study:
- To evaluate the efficacy of oral amiodarone in patients with atrial fibrillation.
- To assess amiodarone for rate control, paroxysmal atrial fibrillation prophylaxis, and post-conversion rhythm maintenance.
Main Methods:
- Oral amiodarone (200 mg daily) was administered to 27 patients.
- Patients were treated for rate control (9), paroxysmal AF prophylaxis (8), or post-DC conversion prophylaxis (13).
- Patients were refractory to other antiarrhythmic drugs.
Main Results:
- Amiodarone provided complete cessation or marked reduction in paroxysmal atrial fibrillation attacks in 8 patients.
- 10 of 13 patients maintained sinus rhythm longer with amiodarone after DC conversion.
- Amiodarone was effective in moderating ventricular response in atrial fibrillation for 9 patients.
- 3 patients discontinued treatment due to side effects.
Conclusions:
- Oral amiodarone is effective for preventing atrial fibrillation episodes and recurrence after cardioversion.
- Amiodarone serves as a valuable option for ventricular rate control when other treatments fail.